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Can melatonin supplementation improve cardiometabolic parameters of overweight night workers?
Night work leads to the suppression of melatonin production due to exposure to light at night. Work at night is also associated with cardiometabolic disturbances. This raises the hypothesis that supplementation of this hormone might be used to reduce the deleterious effects caused by this exposure. However, studies assessing the effectiveness of this treatment in humans are scarce.
To verify whether melatonin supplementation improves cardiometabolic parameters in overweight night workers.
A randomized clinically controlled double-blind crossover trial involving 26 nursing professionals working permanent night shifts (12 hours on, 36 hours off) was conducted. The intervention was carried out in two stages (each lasting 3 months) and entailed administration of 3 mg of fast-releasing melatonin or placebo on nights of non-working days or of days off. Cardiovascular and metabolic parameters (glucose, glycated hemoglobin, insulin, total cholesterol, HDL-cholesterol, LDL-cholesterol, VLDL-cholesterol, triglycerides, blood pressure and heart rate at rest) were assessed at baseline and after each stage. Variability in cardiometabolic parameters was determined by the difference between means test.
Mean age of participants was 37.8 (SE = 1.1 years-old). Most participants worked as nurses (53.8%) and were married (65.5%). Mean time working night shifts was 4.8 (SE = 0.8 years). After melatonin supplementation, no significant effects were found in the improvement of cardiometabolic parameters.
The intermittent supplementation of 3 mg of melatonin for 3 months was not effective to improve the cardiometabolic parameters of overweight night workers. Further studies are needed to investigate the individual level of melatonin in order to adjust the dose and time of supplementation.
Melatonin, Clinical trial, Night workers, Cardiometabolic parameters, Excess weight.
Institute of Biomedical Sciences, University of São Paulo (SP), Brazil - São Paulo - Brasil, Center for Applied Social Sciences and Health, Nutrition Course, Catholic University of Santos (SP), Brazil - São Paulo - Brasil, Center for Applied Social Sciences and Health,Nursing Course, Catholic University of Santos (SP), Brazil - São Paulo - Brasil, Department of Epidemiology, Post-Graduate Program in Public Health, Catholic University of Santos (SP), Brazil - São Paulo - Brasil, Department of Health, Life Cycles and Society, School of Public Health, University of São Paulo (SP), Brazil - São Paulo - Brasil, g College of Health Sciences, Abu Dhabi University, United Arab Emirates - - Emirados Árabes Unidos, Stress Research Institute, University of Stockholm, Sweden - - Suécia
Patrícia Teixeira de Santana , Adriana de Sousa Duarte, Ananda Laís Felix Garrido, Gabriella Habib Rodrigues , Pollyanna Pellegrino , Luciana Fildalgo Ramos Nogueira , José Cipolla-Neto, Claudia Roberta de Castro Moreneo, Elaine Cristina Marqueze