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Título

EFFECTS OF INFLAMMATION AND BODY COMPOSITION ON EXCESSIVE DAY SLEEPING

Introdução

Excessive daytime sleepiness (EDS) can be defined as an increase in the propensity to sleep in inappropriate circumstances, affecting professional, family and social activities. It is known that overweight and obesity are factors highly related to EDS, but it is also observed that both pathologies related to low-grade inflammation and most metabolic diseases have higher values related to increased oxidative stress biomarkers. The direct relationship between changes in the ideal nutritional status (obesity), cardiovascular, neurodegenerative, metabolic and inflammatory diseases and the increase in oxidative stress is already consolidated.

Objetivo

To relate the measures of inflammation and body composition with daytime sleepiness in health workers.

Métodos

Cross-sectional, quantitative, prospective research, being part of the doctoral thesis, whose CAAE number is 33140620.6.0000.8050. Twenty-four individuals participated in this sample, with a mean age of 36.5 years ±5.8. Of these, 50% of the sample (n=12) had an exclusively day shift and the rest mixed shift (night and day). The mean BMI was 26.9±2.5, indicating overweight in 75% of the sample (n=18). Epwort's sleepiness scale was used to assess EDS, to assess peripheral inflammation, ultrasensitive C-reactive protein (CRP) was used, and the assessment of body composition was performed using the Bioelectrical Impedance (BIA) method using the analyzer of body composition Inbody S10®, being considered the items BMI, Skeletal Muscle Mass (SMM). There was a positive Spearman correlation between sleepiness and inflammation (p<0.05). To assess the relationships between MME, BMI and EDS, linear regression was used, obtaining p < 0.0001 between the variables. There was no statistical relationship established between the type of working hours and the SDE.

Resultados

It is known that unsaturated free fatty acids are high in the systemic circulation in overweight/obese humans; and that tissues with unsaturated lipid characteristics may be associated with the synthesis of prostaglandins, precursors of the inflammatory process and potent sleep-inducing humoral factors.

Conclusões

Overweight and low-grade inflammation biochemically influence the manifestation of EDS. We suggest further research involving biochemical markers and sleep latency.

Palavras-chave

Disorders of Excessive Somnolence; Inflammation Mediators; Obesity.

Área

Área Clínica

Autores

MARTA MARIA DA SILVA LIRA BATISTA, MARCELA SILAGI, RAIMUNDA SHEYLA CARNEIRO DIAS, GABRIELLY MARTINS DE BARROS, MYCAELE ALINE SANTANA SOUSA, MARIA DO CARMO DE CARVALHO E MARTINS